Los efectos de la obesidad sobre el cerebro y la cognición
DOI:
https://doi.org/10.33064/iycuaa2023894205Palabras clave:
obesidad, sobrepeso, cognición, cerebro, enfermedades neurodegenerativasResumen
Se ha reportado que la obesidad y el sobrepeso inflaman crónicamente al cerebro, hecho que puede producir muerte neuronal, degeneración de la sustancia blanca, y ulteriormente, influir en un bajo desempeño cognitivo. La obesidad es un factor de riesgo de deterioro cognitivo o, incluso, algunos tipos de demencia durante el envejecimiento. Por lo tanto, es necesario concientizar a los lectores sobre los peligros en su salud física y mental cuando se tiene un estilo de vida que promueve la obesidad y el sobrepeso.
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• Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018). Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. Frontiers in neuroscience, 12, 155. doi: 10.3389/fnins.2018.00155
• Beydoun, M. A., Beydoun, H. A., & Wang, Y. (2008). Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obesity reviews: an official journal of the International Association for the Study of Obesity, 9(3), 204–218. doi: 10.1111/j.1467-789X.2008.00473.x
• Cholerton, B., Baker, L. D., & Craft, S. (2011). Insulin resistance and pathological brain ageing. Diabetic medicine : a journal of the British Diabetic Association, 28(12), 1463–1475. doi: 10.1111/j.1464-5491.2011.03464.x
• Coll-Padrós, N., León, M., Valech, N., Ros, E., Vidal, J., Estruch, R., … Rami, L. (2019). Physical activity is associated with better global cognition and frontal function in overweight/obese older adults with metabolic syndrome. European review of aging and physical activity: official journal of the European Group for Research into Elderly and Physical Activity, 16, 23. doi: 10.1186/s11556-019-0229-y
• Dávila-Torres, J., González-Izquierdo, J. J., & Barrera-Cruz, A. (2015). Panorama de la obesidad en México [Obesity in Mexico]. Revista médica del Instituto Mexicano del Seguro Social, 53(2), 240–249.
• Elias, M. F., Elias, P. K., Sullivan, L. M., Wolf, P. A., & D'Agostino, R. B. (2005). Obesity, diabetes and cognitive deficit: The Framingham Heart Study. Neurobiology of aging, 26 Suppl 1, 11–16. doi: 10.1016/j.neurobiolaging.2005.08.019
• Favieri, F., Forte, G., & Casagrande, M. (2019). The Executive Functions in Overweight and Obesity: A Systematic Review of Neuropsychological Cross-Sectional and Longitudinal Studies. Frontiers in psychology, 10, 2126. doi: 10.3389/fpsyg.2019.02126
• Gómez-Apo, E., García-Sierra, A., Silva-Pereyra, J., Soto-Abraham, V., Mondragón-Maya, A., Velasco-Vales, V., & Pescatello, L. S. (2018). A Postmortem Study of Frontal and Temporal Gyri Thickness and Cell Number in Human Obesity. Obesity (Silver Spring, Md.), 26(1), 94–102. doi: 10.1002/oby.22036
• Gunstad, J., Lhotsky, A., Wendell, C. R., Ferrucci, L., & Zonderman, A. B. (2010). Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging. Neuroepidemiology, 34(4), 222–229. doi: 10.1159/000297742
• Heckmann, B. L., Tummers, B., & Green, D. R. (2019). Crashing the computer: apoptosis vs. necroptosis in neuroinflammation. Cell death and differentiation, 26(1), 41–52. doi: 10.1038/s41418-018-0195-3
• Herrmann, M. J., Tesar, A. K., Beier, J., Berg, M., & Warrings, B. (2019). Grey matter alterations in obesity: A meta-analysis of whole-brain studies. Obesity reviews: an official journal of the International Association for the Study of Obesity, 20(3), 464–471. doi: 10.1111/obr.12799
• Horvath, T.L., Sármán, B., García-Cáceres, C., Enriori, P.J., Sótonyi, P., Shanabrough, M… Tschöp, M.H. (2010). Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proceedings of the National Academy of Sciences, 107, 14875 - 14880.
• Kaufer-Horwitz, M. & Pérez-Hernández, J.F. (2022). La obesidad: aspectos fisiopatológicos y clínicos. Inter disciplina, 10(26). doi: 10.22201/ceiich.24485705e.2022.26.80973
• Kenny P. J. (2011). Reward mechanisms in obesity: new insights and future directions. Neuron, 69(4), 664–679. doi: 10.1016/j.neuron.2011.02.016
• Kullmann, S., Callaghan, M. F., Heni, M., Weiskopf, N., Scheffler, K., Häring, H. U., … Preissl, H. (2016). Specific white matter tissue microstructure changes associated with obesity. NeuroImage, 125, 36–44. doi: 10.1016/j.neuroimage.2015.10.006Lowe, C. J., Morton, J. B., & Reichelt, A. C. (2020). Adolescent obesity and dietary decision making-a brain-health perspective. The Lancet. Child & adolescent health, 4(5), 388–396. doi: 10.1016/S2352-4642(19)30404-3
• Miller, A. A., & Spencer, S. J. (2014). Obesity and neuroinflammation: a pathway to cognitive impairment. Brain, behavior, and immunity, 42, 10–21. doi: 10.1016/j.bbi.2014.04.001
• Moraes, J. C., Coope, A., Morari, J., Cintra, D. E., Roman, E. A., Pauli, J. R., … Velloso, L. A. (2009). High-fat diet induces apoptosis of hypothalamic neurons. PloS one, 4(4), e5045. doi: 10.1371/journal.pone.0005045
• Nguyen, J. C., Killcross, A. S., & Jenkins, T. A. (2014). Obesity and cognitive decline: role of inflammation and vascular changes. Frontiers in neuroscience, 8, 375. doi: 10.3389/fnins.2014.00375
• Organización Mundial de la Salud, OMS. (junio, 2021). Obesidad y sobrepeso. Recuperado de: https://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight
• Organización Mundial de la Salud, OMS (marzo, 2023). Obesity. Recuperado de: https://www.who.int/health-topics/obesity#tab=tab_1
• Ou, X., Andres, A., Pivik, R. T., Cleves, M. A., & Badger, T. M. (2015). Brain gray and white matter differences in healthy normal weight and obese children. Journal of magnetic resonance imaging: JMRI, 42(5), 1205–1213. doi: 10.1002/jmri.24912
• Sadowska, J., Gębczyński, A. K., & Konarzewski, M. (2017). Metabolic risk factors in mice divergently selected for BMR fed high fat and high carb diets. PloS one, 12(2), e0172892. doi: 10.1371/journal.pone.0172892
• Smith, E., Hay, P., Campbell, L., & Trollor, J. N. (2011). A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment. Obesity reviews : an official journal of the International Association for the Study of Obesity, 12(9), 740–755. doi: 10.1111/j.1467-789X.2011.00920.x
• Sun, X., Li, Y., Cai, L., & Wang, Y. (2021). Effects of physical activity interventions on cognitive performance of overweight or obese children and adolescents: a systematic review and meta-analysis. Pediatric research, 89(1), 46–53. doi: 10.1038/s41390-020-0941-3
• Tanaka, H., Gourley, D. D., Dekhtyar, M., & Haley, A. P. (2020). Cognition, Brain Structure, and Brain Function in Individuals with Obesity and Related Disorders. Current obesity reports, 9(4), 544–549. doi: 10.1007/s13679-020-00412-y
• Tang, X., Zhao, W., Lu, M., Zhang, X., Zhang, P., Xin, Z….Stehouwer, C. D. A. (2021). Relationship between Central Obesity and the incidence of Cognitive Impairment and Dementia from Cohort Studies Involving 5,060,687 Participants. Neuroscience and biobehavioral reviews, 130, 301–313. doi: 10.1016/j.neubiorev.2021.08.028
• Van Opdenbosch, N., & Lamkanfi, M. (2019). Caspases in Cell Death, Inflammation, and Disease. Immunity, 50(6), 1352–1364. doi: 10.1016/j.immuni.2019.05.020
• Zapata, R. C., Carretero, M., Reis, F. C. G., Chaudry, B. S., Ofrecio, J., Zhang, D., … Osborn, O. (2022). Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase. Nature communications, 13(1), 5092. doi: 10.1038/s41467-022-32764-5
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Derechos de autor 2023 Martina Ferrari-Díaz, Juan Felipe Silva-Pereyra
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Las obras publicadas en versión electrónica de la revista están bajo la licencia Creative Commons Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
