Allergic asthma: immunological mechanisms, pathophysiology and current treatments
DOI:
https://doi.org/10.33064/iycuaa2015653584Keywords:
asthma prevalence, asthma phenotypes, allergic asthma, TH2-cytokines, airway remodeling, treatmentsAbstract
Asthma is a chronic inflammatory lung disease that affects more than 300 million persons all over the world, resulting in approximately 250,000 annual deaths. Allergic asthma is the most common clinical phenotype of the disease. Its etiology involves
multiple genetic and environmental factors. Many inflammatory cells, including mast cells, eosinophils, neutrophils, T lymphocytes and epithelial cells, play crucial roles in its development. Inflammatory mediators released by these cells cause sustained chronic inflammation, triggering bronchoconstriction and structural changes in the airways. Understanding the exact immunological mechanisms involved in the development of allergic asthma is crucial to generate new treatments. The aim of this work is to
review the most recent information on molecular and cellular elements associated with allergic asthma, its pathophysiology and current treatments.
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De páginas electrónicas
• GINA (GLOBAL INICIATIVE FOR ASTHMA). Recuperado el 5 de mayo de 2014, de http://www.ginasthma.org/
• INER (INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS). Recuperado el 2 de abril de 2014, de http://www.iner.salud.gob.mx/
• OMS (ORGANIZACIÓN MUNDIAL DE LA SALUD). Recuperado el 1 de mayo de 2014, de http://www.who.int/es/
• SSA (SECRETARÍA DE SALUD) DIRECCIÓN GENERAL DE EPIDEMIOLOGÍA. Recuperado el 9 de junio de 2014, de http://www.epidemiologia.salud.gob.mx/
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Copyright (c) 2015 Nuria Renata Roldán Bretón, Mariela Jiménez Vargas, Eva Salinas Miralles
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