Hidroxiapatita y selenio: Protagonistas emergentes en la lucha contra el cáncer
DOI:
https://doi.org/10.33064/iycuaa2024914268Palabras clave:
Hidroxiapatita, selenio, mercurio, efectos, ADN, cáncer, nanopartículas, citotoxicidad, síntesisResumen
La hidroxiapatita sintética (sHap) es un material biomimético con propiedades remarcables; es biocompatible y biodegradable, por lo que es asimilado por el cuerpo humano. Además de sus conocidas aplicaciones en ingeniería de tejidos, la sHap han mostrado ser una candidata prometedora para combatir el cáncer, actuando principalmente como una matriz para otros agentes terapéuticos. Presenta una estructura química con gran potencial para sustitución iónica con el objetivo de incrementa sus características y propiedades de manera sostenida, prolongada y dirigida contra el cáncer. La incorporación de elementos específicos, como el selenio (Se), coadyuva en la inhibición del crecimiento y propagación de células cancerosas, además de favorecer una respuesta inmunitaria, y prevención. Este documento es una revisión actual de los métodos de obtención de la sHap y su dopaje con Se. Discutimos aspectos de biocompatibilidad y citotoxicidad, además de su efecto documentado tanto en células sanas como cancerosas.
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Derechos de autor 2024 Susana López-Ortiz, Daniela Salado-Leza
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