Función de los NPY-Y1 de la sustancia gris periacueductal dorsal (SGP-D) en conductas de consumo hedónico en ratas Wistar
DOI:
https://doi.org/10.33064/iycuaa2023883782Palabras clave:
NPY, NPY-Y1, BIBP-3226, consumo de alimento, alcoholismo, sustancia gris periacueductalResumen
En modelos preclínicos, los efectos del neuropéptido Y (NPY) en la sustancia gris periacueductal dorsal (SGP-D) incluyen alteraciones en ansiedad y consumo de alimento, pero los receptores involucrados y/o su ubicación no se han descrito a profundidad. Nuestro objetivo fue analizar los efectos farmacológicos de la estimulación/bloqueo de los receptores NPY-Y1 en la SGP-D sobre conductas homeostáticas/hedónicas naturales y preferencia etílica en ratas Wistar hembras y machos (250-270 g). Lo animales recibieron inyecciones intra-SGP-D (n=9) con: (i) vehículo (DMSO 10%); (ii) neuropéptido-Y (NPY, agonista endógeno NPY-Y1); o (iii) BIBP-3226 (antagonista selectivo NPY-Y1). NPY aumentó el consumo de alimento y sacarosa (p < 0.05) en hembras y machos, sin modificar la preferencia etílica. BIBP-3226 disminuyó la ingestión de ambas sustancias y aumentó la preferencia etílica. Se concluye que el receptor NPY-Y1 en la SGP-D regula conductas de consumo predominantemente hedónico (tanto naturales como vinculadas con abuso alcohólico).
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Derechos de autor 2023 Abraham Miranda-Páez, Priscila Vázquez-León, Adán Rodríguez-Hernández, Bruno Antonio Marichal-Cancino
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Las obras publicadas en versión electrónica de la revista están bajo la licencia Creative Commons Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
