Beyond nodular glomerulosclerosis. Case report

Abstract

Introduction: Nodular glomerulosclerosis has traditionally been recognized as a pathognomonic lesion of diabetic nephropathy. However, it has become evident that this condition can occur in the absence of diabetes, albeit less frequently. Objective: This case report presents a patient who developed nodular glomerulosclerosis without the presence of classical risk factors such as diabetes mellitus, hypertension, or smoking. Methods: A retrospective case study of a patient who required hemodialysis due to acute kidney injury is presented. A comprehensive review of the medical history, including family history, lifestyle, and laboratory results, was conducted. A renal biopsy was performed to confirm the histopathological diagnosis. Results: The patient, without a history of relevant chronic diseases, presented with proteinuria and hematuria. Histopathological findings from the renal biopsy confirmed the diagnosis of idiopathic nodular glomerulosclerosis. The initiation of hemodialysis led to a significant improvement in the patient’s clinical condition. Conclusion: Idiopathic nodular glomerulosclerosis represents a complex clinical entity with an as yet incompletely elucidated pathophysiology. Further research is required to understand the underlying molecular mechanisms and develop more specific therapeutic strategies for this patient population.

Recepción: 25/01/2025

Aprobación: 28/02/2025