Genética del sobrepeso y la obesidad en niños y adolescentes mexicanos

Autores/as

DOI:

https://doi.org/10.33064/iycuaa2022863630

Palabras clave:

Sobrepeso, obesidad, genes, polimorfismos genéticos, niños mexicanos, adolescentes mexicanos

Resumen

El sobrepeso y la obesidad afectan a más 340 millones de niños y adolescentes alrededor del mundo, lo que constituye un problema grave de salud pública. La obesidad es una enfermedad multifactorial ocasionada principalmente por mala alimentación y baja actividad física, aunque también existen factores genéticos que desempeñan un papel importante en su desarrollo. El objetivo fue realizar una revisión bibliográfica para identificar genes asociados con sobrepeso y obesidad en niños y adolescentes mexicanos. El 36% de los genes analizados, 8/22, mostraron asociación significativa para sobrepeso/obesidad, dichos genes son: FGF21, FTO, GNPDA2, HP, MC4R, PAI1, PCSK1 y PON1. Entonces, se puede afirmar que la genética tiene un rol importante en la etiología del sobrepeso y la obesidad en niños y adolescentes mexicanos. Sin embargo, se debe recordar que la alimentación hipercalórica y la falta de ejercicio, siguen siendo las causas principales del sobrepeso y la obesidad común alrededor del mundo.

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Biografía del autor/a

Angélica López-García, Universidad Autónoma de Tamaulipas

Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros

Verónica Judith Picos-Cárdenas, Universidad Autónoma de Sinaloa

Laboratorio de Genética, Facultad de Medicina, Universidad Autónoma de Sinaloa; Núcleo Académico Básico de Posgrado de la Facultad de Ciencias de la Nutrición y Gastronomía

Evelia Leal-Ugarte, Universidad Autónoma de Tamaulipas

Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros

Saúl Armando Beltrán-Ontiveros, Universidad Autónoma de Sinaloa

Centro de Investigación y Docencia en Ciencias de la Salud, Hospital Civil de Culiacán

Juan Pablo Meza-Espinoza, Universidad Autónoma de Tamaulipas

Facultad de Medicina e Ingeniería en Sistemas Computacionales de Matamoros

Citas

• Aguiar, L., Marinho, C., Martins, R., Alho, I., Ferreira, J., Levy, P., … Inacio, A. (2019). Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children. Cell Mol Biol (Noisy-le-grand), 65(2), 69-74. https://pubmed.ncbi.nlm.nih.gov/30860476/

• Bradfield, J. P., Vogelezang, S., Felix, J. F., Chesi, A., Helgeland, O., Horikoshi, M., … Grant, S. F. A. (2019). A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Hum Mol Genet, 28(19), 3327-3338. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859434/

• Costa-Urrutia, P., Abud, C., Franco-Trecu, V., Colistro, V., Rodríguez-Arellano, M. E., Alvarez-Fariña, R., … Granados, J. (2020a). Effect of 15 BMI-associated polymorphisms, reported for Europeans, across ethnicities and degrees of Amerindian ancestry in Mexican children. Int J Mol Sci, 21(2), 374. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013683/

• Costa-Urrutia, P., Flores-Buendía, A. M., Ascencio-Montiel, I., Solares-Tlapechco, J., Medina-Campos, O. N., Pedraza-Chaverri, J., … Rodríguez-Arellano, M. E. (2020b). Antioxidant enzymes haplotypes and polymorphisms associated with obesity in Mexican children. Antioxidants (Basel), 9(8), 684. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464274/

• Creemers, J. W., Choquet, H., Stijnen, P., Vatin, V., Pigeyre, M., Beckers, S., … Meyre, D. (2012). Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes, 61(2), 383-390. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266396/

• De la Cruz-Mosso, U., Ramos-Arellano L. E., Muñoz-Valle, J. F., Salgado-Bernabé, A. B., Salgado-Goytia, L., Castro-Alarcón, N., … Parra-Rojas, I. (2016). PAI-1 haplogenotype confers genetic susceptibility for obesity and hypertriglyceridemia in Mexican children. Invest Clin, 57(3), 246-58.

• Dina, C., Meyre, D., Gallina, S., Durand, E., Korner, A., Jacobson, P., … Froguel, P. (2007). Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet, 39(6), 724-726. doi: 10.1038/ng2048

• Fatima, M. T., Ahmed, I., Fakhro, K. A., & Akil, A. S. A. (2022). Melanocortin-4 receptor complexity in energy homeostasis, obesity and drug development strategies. Diabetes Obes Metab, 2024, 1-16. https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14618

• Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., … McCarthy, M. I. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646098/

• García-Solís, P., Reyes-Bastidas, M., Flores, K., García, O. P., Rosado, J. L., Méndez-Villa, L., …Solís-Sáinz, J. C. (2016). Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children. British Journal of Nutrition, 116(10), 1834-1840. doi: 10.1017/S0007114516003779

• González-Herrera, L., Zavala-Castro, J., Ayala-Cáceres, C., Pérez-Mendoza, G., López-González, M. J., Pinto-Escalante, D., … Alcocer-Gamboa, A. (2019). Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight. Am J Hum Biol, 31(1), e23192. doi: 10.1002/ajhb.23192.

• Google. (20 de 07 de 2022). Scholar google. Obtenido de https://scholar.google.com/

• Heindel, J. J., Howard, S., Agay-Shay, K., Arrebola, J. P., Audouze, K., Babin, P. J., . . . Roepke, T. A. (2022). Obesity II: Establishing causal links between chemical exposures and obesity. Biochemical Pharmacology, 199, 115015. doi:10.1016/j.bcp.2022.115015

• Hoffstedt, J., Andersson, I. L., Persson, L., Isaksson, B., & Arner, P. (2002). The common -675 4G/5G polymorphism in the plasminogen activator inhibitor -1 gene is strongly associated with obesity. Diabetologia, 45(4), 584-587. doi: 10.1007/s00125-001-0774-5.

• Huen, K., Harley, K., Beckman, K., Eskenazi, B., & Holland, N. (2013). Associations of PON1 and genetic ancestry with obesity in early childhood. PLoS One, 8(5), e62565. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643931/

• Institute of Human Genetics, Munich University of Technology. (2022). Tests for deviation from Hardy-Weinberg equilibrium and tests for association. https://ihg.helmholtz-muenchen.de/cgi-bin/hw/hwa1.pl

• Jarvela, T. S., Shakya, M., Bachor, T., White, A., Low, M. J., & Lindberg, I. (2019). Reduced stability and pH-dependent activity of a common obesity-linked PCSK1 polymorphism, N221D. Endocrinology, 160(11), 2630-2645. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892424/

• Katzmarzyk, P. T., Perusse, L., Rao, D. C., & Bouchard, C. (2000). Familial risk of overweight and obesity in the Canadian population using the WHO/NIH criteria. Obes Res 2000, 8(2), 194-197. https://onlinelibrary.wiley.com/doi/epdf/10.1038/oby.2000.21

• Klunder-Klunder, M., Mejía-Benítez, M. A., Flores-Huerta, S., Burguete-García, A. I., García-Mena, J., & Cruz, M. (2011). rs12255372 variant of TCF7L2 gene is protective for obesity in Mexican children. Arch Med Res, 42(6), 495-501. doi: 10.1016/j.arcmed.2011.05.006.

• Kulaeva, E. D., Volchik, V. V., Bocharova, O. V., Teplakova, E. D., Shkurat, M. A., Derevyanchuk, E. G., & Mashkina, E. V. (2021). Association of SNPs in lipid metabolism gene single nucleotide polymorphism with the risk of obesity in children. Genet Test Mol Biomarkers, 25(6), 419-425. https://www.liebertpub.com/doi/epdf/10.1089/gtmb.2020.0343

• Kupczyk. D., Bilski, R., Sokołowski, K., Pawłowska, M., Wozniak, A., Szewczyk-Golec, K. (2019). Paraoxonase 1: The Lectin-like oxidized LDL receptor type I and oxidative stress in the blood of men with type II obesity. Dis Markers, 2019, 6178017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815624/

• Lan, N., Lu, Y., Zhang, Y., Pu, S., Xi, H., Nie, X., … Yuan, W. (2020). FTO - A common genetic basis for obesity and cancer. Front Genet, 11, 559138. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701174/

• Li, J. M., Li, Y., & Wang, L. (2017). The genetic association between PON1 polymorphisms and osteonecrosis of femoral head: A case-control study. Medicine (Baltimore), 96(42), e8198. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662370/

• Littleton, S. H., Berkowitz, R. I., & Grant, S. F. (2020). Genetic determinants of childhood obesity. Mol Diagn Ther, 24(6), 653-663. doi:10.1007/s40291-020-00496-1

• López-Rodríguez, G., Estrada-Neria, A., Suárez-Diéguez, T., Tejero, M. E., Fernández, J. C., & Galván, M. (2020). Common polymorphisms in MC4R and FTO genes are associated with BMI and metabolic indicators in Mexican children: Differences by sex and genetic ancestry. Gene, 754, 144840. doi: 10.1016/j.gene.2020.144840

• Lowry, R. (22 de 07 de 2022). Vassarstats. Obtenido de vassarstats.net: http://vassarstats.net/odds2x2.html

• Martin, B., DeWitt, P. E., Russell, S., Anand, A., Bradwell, K. R., Bremer, C., … Bennett, T. D. (2022). Characteristics, outcomes, and severity risk factors associated with SARS-CoV-2 infection among children in the US national COVID cohort collaborative. JAMA Netw Open, 5(2), e2143151. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826172/

• Martínez-Ezquerro, J. D., Rendón-Macías, M. E., Zamora-Mendoza, G., Serrano-Meneses, J., Rosales-Rodríguez, B., Escalante-Bautista, D., … Rosas-Vargas, H. (2017). Association between the brain-derived neurotrophic factor Val66Met polymorphism and overweight/obesity in pediatric population. Arch Med Res, 48(7), 599-608. doi: 10.1016/j.arcmed.2018.02.005

• Martos-Moreno, G. A., Serra-Juhé, C., Pérez-Jurado, L. A., & Argente, J. (2017). Aspectos genéticos de la obesidad. Rev Esp Endocrinol Pediatr, 8 (Suppl), 21-32. https://www.endocrinologiapediatrica.org/revistas/P1-E22/P1-E22-S1079-A391.pdf

• Mejía-Benítez, A., Klunder-Klunder, M., Yengo, L., Meyre, D., Aradillas, C., Cruz, E., … Bonnefond, A. (2013). Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Medical Genetics, 14, 21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577489/

• Mendes Resende, C. M., Macedo da Silva, H. A. M., Porto Campello, C., Amaral Ferraz, L. A., Santos de Lima, E. L., Aparecida Beserra, M., … Pereira da Silva, L. M. (2021). Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: A systematic review. Nutrition, 91-92, 111474. doi: 10.1016/j.nut.2021.111474

• Morange, P. E., Saut, N., Alessi, M. C., Yudkin, J. S., Margaglione, M., Di Minno, G., … Ju Han-Vague, I. (2007). Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HI FMECH study. Arterioscler Thromb Vasc Biol 27(10), 2250-2257. doi: 10.1161/ATVBAHA.107.149468

• NLM, N. C. (20 de 07 de 2022). Pubmed Home. Obtenido de Pubmed: https://pubmed.ncbi.nlm.nih.gov

• OMS. (25 de 07 de 2022). OMS. Obtenido de OMS: https://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight#:~:text=En%20el%20caso%20de%20los,igual%20o%20superior%20a%2030.

• Peralta Romero, J. J., Karam Araujo, R., Burguete García, A. I., Estrada Velasco, B. I., López Islas, C., Figueroa Arredondo, P. M. C., … & Cruz, M. (2015). ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children. Boletín Médico del Hospital Infantil de México, 72(1), 26-33. doi: 10.1016/j.bmhimx.2015.02.002

• Pillay, V., Crowther, N. J., Ramsay, M., Smith, G. D., Norris, S. A., & Lombard, Z. (2015). Exploring genetic markers of adult obesity risk in black adolescent South Africans-the birth to twenty cohort. Nutr Diabetes, 5(6), e157. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491859/

• Pyrzak, B., Demkow, U., & Kucharska, A. M. (2015). Brown adipose tissue and browning agents: Irisin and FGF21 in the development of obesity in children and adolescents. Adv Exp Med Biol, 866, 25-34. doi: 10.1007/5584_2015_149

• Ruiz-Padilla, A. J., Morales-Hernández, G., Ruiz-Noa, Y., Alonso-Castro, A. J., Lazo-de-la-Vega-Monroy, M. L., Preciado-Puga, M. D. C., … Ibarra-Reynoso, L. D. R. (2019). Association of the 3'UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity. J Pediatr Endocrinol Metab, 32(9), 921-928. doi: 10.1515/jpem-2018-0546

• Salinas-Santander, M. A., León-Cachón, R. B., Cepeda-Nieto, A. C., Sánchez-Domínguez, C. N., González-Zavala, M. A., Gallardo-Blanco, H. L., … González-Madrazo, M. A. (2016). Assessment of biochemical parameters and characterization of TNF α -308G/A and PTPN22 +1858C/T gene polymorphisms in the risk of obesity in adolescents. Biomed Rep, 4(1), 107-111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726844/

• Shamah-Levy, T., Campos-Nonato, I., Cuevas-Nasu, L., Hernández-Barrera, L., Morales-Ruán, M. C., Rivera-Dommarco, J., & Barquera, S. (2019). Overweight and obesity in Mexican vulnerable population. Results of Ensanut 100k. Salud Publica Mex, 61(6), 852-865. https://www.medigraphic.com/pdfs/salpubmex/sal-2019/sal196q.pdf

• Shamah-Levy, T., Cuevas-Nasu, L., Gaona-Pineda, E. B., Gómez-Acosta, L. M., Morales-Ruán, M. C., Hernández-Ávila, M., & Rivera-Dommarco, J. A. (2018). Sobrepeso y obesidad en niños y adolescentes en México, actualización de la Encuesta Nacional de Salud y Nutrición de Medio Camino 2016. Salud Publica Mex, 60(3), 244-253. https://www.medigraphic.com/pdfs/salpubmex/sal-2018/sal183e.pdf

• Sonestedt, E., Roos, C., Gullberg, B., Ericson, U., Wirfalt, E., & Orho-Melander, M. (2009). Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr, 90(5), 1418-1425. doi: 10.3945/ajcn.2009.27958

• Sulimai, N. H., Brown, J., & Lominadze, D. (2022). Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 proteins, and their effects. Biomedicines, 10(7), 1712. doi: 10.3390/biomedicines10071712

• Tang, Y., Jin, B., Zhou, L., & Lu, W. (2017). MeQTL analysis of childhood obesity links epigenetics with a risk SNP rs17782313 near MC4R from meta-analysis. Oncotarget, 8(2), 2800-2806. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356842/

• Tanofsky-Kraff, M., Han, J. C., Anandalingam, K., Shomaker, L. B., Columbo, K. M., Wolkoff, L. E., … Yanovski, J. A. (2009). The FTO gene rs9939609 obesity-risk allele and loss of control overeating. Am J Clin Nutr, 90(6), 1483-1488. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777464/

• Tomei, S., Mamtani, R., Al Ali, R., Elkum, N., Abdulmalik, M., Ismail, A., … Chouchane, L. (2015). Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population. J Transl Med, 13:119. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422146/

• Vázquez-Moreno, M., Locia-Morales, D., Pérez-Herrera, A., Gómez-Díaz, R. A., González-Dzib, R., Valdez-González, A. L., … Meyre, D. (2020). Causal association of haptoglobin with obesity in Mexican children: A Mendelian randomization study. J Clin Endocrinol Metab, 105(7), dgaa213. doi: 10.1210/clinem/dgaa213

• Villalobos-Comparán, M., Villamil-Ramírez, H., Villarreal-Molina, T., Larrieta-Carrasco, E., León-Mimila, P., Romero-Hidalgo, S., … Canizales-Quinteros, S. (2012). PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population. PLoS ONE, 7(6), e39037. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380862/

• Wan, B. N., Zhou, S. G., Wang, M., Zhang, X., & Ji, G. (2021). Progress on haptoglobin and metabolic diseases. World J Diabetes, 12(3), 206-214. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958475/

• Willer, C. J., Speliotes, E. K., Loos, R. J., Li, S., Lindgren, C. M., Heid, I. M., …Genetic Investigation of Anthropometric Traits Consortium. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet, 41(1), 25-34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695662/

• Wu, L., Ma, F., Zhao, X., Zhang, M. X., Wu, J., & Mi, J. (2019). GNPDA2 gene affects adipogenesis and alters the transcriptome profile of human adipose-derived mesenchymal stem cells. Int J Endocrinol, 2019, 9145452. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701328/

• Wu, L., Xi, B., Zhang, M., Shen, Y., Zhao, X., Cheng, H., … Mi, J. (2010). Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes, 59(12), 3085-3089. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992769/

• Zhang, M., Zeng, L., Wang, Y. J., An, Z. M., & Ying, B. W. (2012). Associations of fibroblast growth factor 21 gene 3' untranslated region single-nucleotide polymorphisms with metabolic syndrome, obesity, and diabetes in a Han Chinese population. DNA Cell Biol, 31(4), 547-552. doi: 10.1089/dna.2011.1302

• Zhang, Y., Liu, D., Long, X. X., Fang, Q. C., Jia, W. P., & Li, H. T. (2021). The role of FGF21 in the pathogenesis of cardiovascular disease. Chin Med J (Engl), 134(24), 2931-2943. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710326/

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2022-08-31

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