Drug-resistance tuberculosis: Molecular mechanisms of Mycobacterium tuberculosis
DOI:
https://doi.org/10.33064/iycuaa2024914559Keywords:
tuberculosis, Mycobacterium tuberculosis, mutation, drug-resistance tuberculosis, genesis and evolutionAbstract
In this traditional review, we describe factors from both Mycobacterium tuberculosis (M. tb) and the host that are associated for tuberculosis drug-resistant. We review mutation rate, genetic diversity, innate resistance, metabolic rate, bacilli population hetereogeneity, epistatis of M. tb that promote its resistance against most anti-tuberculosis drug treatment. We also describe how granuloma heterogeneity affects the activity of anti-tuberculosis drugs as well as non-compliance of drug treatment promotes the evolution of drug-resistance tuberculosis.
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