Hydroxyapatite and selenium: Emerging players in the fight against cancer
DOI:
https://doi.org/10.33064/iycuaa2024914268Keywords:
Hydroxyapatite, selenium, Hydroxyapatite, selenium, cancer, nanoparticles, cytotoxicity, synthesis., nanoparticles, cytotoxicity, synthesisAbstract
Synthetic hydroxyapatite (sHap) is a biomimetic material with remarkable properties; it is biocompatible and biodegradable, so it is assimilated by the human body. In addition to its known applications in tissue engineering, sHap have shown to be a promising candidate to combat cancer, acting mainly as a matrix for other therapeutic agents. It has a chemical structure with great potential for ionic substitution that increases its characteristics and properties in a sustained, prolonged and targeted manner against cancer. The incorporation of specific elements, such as selenium (Se), helps inhibit the growth and propagation of cancer cells, favors the immune response, and prevents metastasis. This document is a current review of the methods for obtaining sHap and its doping with Se. We discuss aspects of biocompatibility and cytotoxicity, in addition to its documented effect on both healthy and cancer cells.
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