Role of NPY-Y1 from the dorsal periaqueductal gray (SGP-D) in hedonic consumption behaviors in Wistar rats
DOI:
https://doi.org/10.33064/iycuaa2023883782Keywords:
NPY, NPY-Y1, BIBP-3226, food intake, alcoholism, dorsal periacueductal gray (D-PAG)Abstract
In preclinical models, NPYergic transmission in dorsal periaqueductal gray (D-PAG) is involved in anxiety and food intake. Nevertheless, the specific NPY receptors involved remain partially unknown. This study was set-up to investigate the pharmacological effects of stimulation/blockade of NPY1 in D-PAG in Wistar rats (male and female) on food, sucrose, and alcohol intake. Animals received injections (intra-D-PAG; n=9) of: (i) vehicle (DMSO 10%); (ii) neuropeptide-Y (NPY, NPY-Y1 receptor endogenous agonist); or (iii) BIBP-3226 (NPY-Y1 selective receptor antagonist). NPY in D-PAG increased food and sucrose (p < 0.05), but not ethanol (p > 0.05) intake. BIBP-3226 decreased food and sucrose intake (p < 0.05) and increased ethanol consumption (p < 0.05). Our findings suggest NPY-Y1 in D-PAG as a key modulator of consummatory behaviors (mainly hedonic) and ethanol intake.
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