Expression of CD43, pyruvate kinase II and hexokinase II in cervical epidermoid carcinoma
DOI:
https://doi.org/10.33064/iycuaa2019772122Keywords:
cancer cervical, metabolism, protein expression, CD43, pyruvate kinase II, hexokinase IIAbstract
Cervical Cancer (CC) is the second cause of death in Mexico. Infection with the Human Papilloma Virus is a necessary condition during the carcinogenesis process. One of the characteristics of CC is that it presents an altered metabolism; cells tend to more efficiently capture glucose and increase glycolysis. Aberrant glycosylation is a hallmark of cancer, which reflects changes, such as the altered expression of glucosyltransferases and glucosidases. Therefore, the objective of the present work was to describe the expression pattern of CD43, pyruvate kinase II, and hexokinase II in healthy cervical tissue, tissue with CC and in CC cell lines. At this point, we find a higher expression of proteins when compared with healthy tissues. However, there would still be a lack of studies to show if they could be used as a prognostic factor for patients with epidermoid CaCu.
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Copyright (c) 2019 Luz Eugenia Alcántara-Quintana, Verónica Gallegos-García, Yolanda Terán-Figueroa
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