Tuberculosis farmacorresistente: Mecanismos moleculares de Mycobacterium tuberculosis
DOI:
https://doi.org/10.33064/iycuaa2024914559Palabras clave:
Mycobacterium tuberculosis, mutación, tuberculosis fármaco-resistente, evoluciónResumen
Mycobacterium tuberculosis (M. tb), es un patógeno humano altamente exitoso debido a que puede evadir la respuesta inmunológica del hospedero, así como desarrollar fármaco-resistencia a prácticamente todos los antibióticos anti-tuberculosis que se emplean para el tratamiento de la enfermedad. El objetivo de este trabajo fue realizar una revisión descriptiva de los mecanismos del hospedero (heterogeneidad del granuloma, adhesión al tratamiento) y de M. tb (tasa de mutación in vitro e in vivo, diversidad genética, resistencia innata, tasa metabólica, heterogeneidad de las poblaciones del bacilo, y epistasis) que intervienen en el desarrollo de la fármaco-resistencia de la bacteria.
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Derechos de autor 2024 Anaximandro Gomez-Velasco, René Armando Rodríguez-Suárez, Pilar E. Granja-Pérez, Salha M. Villanueva-Jorge, José Q. García-Maldonado
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