Population prevalence of human papillomavirus in women of risk age in Aguascalientes, Mexico

Abstract

The human papillomavirus (HPV) is a double stranded, DNA virus, with more than 200 genotypes identified. It is considered the most frequent sexually transmitted infection. Being the cause of both benign lesion and premalignant lesions and different cancers. The diagnosis of the infection is made by molecular techniques based on the detection of viral DNA, the mRNA of oncogenic proteins and the cellular alteration caused by the infection. Objective: To determine the prevalence of the high-risk stereotypes of human papilloma virus, detected by PCR in patients from the jurisdictions of Aguascalientes state health institute (ISSEA). Methods: This work corresponds to an observational, cross-sectional, retrospective and descriptive study of the samples processed in the Molecular Biology laboratory for HPV detection in the state public health laboratory during the period of January-August 2022. Results: A total of 3,842 cervical smears were performed, of which 3,226 were negative (83.96%). The global prevalence of HPV was 13.8% (n=616). 1.6% (n=64) had HPV 16 infection, 0.6% (n=25) were HPV 18 positive and 11.9% (n=460) were positive to other high-risk strains. The jurisdiction, with the highest prevalence of cases was No. 2, followed by No. 3 and finally No. Conclusions: There is a higher prevalence of infection caused by the serotypes of the high-risk viral pool than HPV 16 and 18 in tested patients, which was significantly higher in those belonging to jurisdiction 2.